Aid workers have warned that some Afghans and Pakistanis made homeless by Monday's earthquake could die from exposure.
There is an urgent need for tents and blankets for those forced to spend a second night outdoors, they said.
Children are especially at risk of succumbing to the extreme cold.
Thousands spent Tuesday night in near-freezing temperatures, reluctant to go back inside for fear of aftershocks, Pakistani media reported.
At least 360 people are known to have died in both countries, but officials are warning the number will rise, particularly in Afghanistan.
The UN children's fund said a combination of intense cold and insecurity were cutting off some communities.
Remote and mountainous quake-affected areas have been hit by heavy rain and snow for the past two days, according to a UNICEF statement.
"Communication is poor and access difficult due to the tough terrain and security operations," the statement says.
Unicef's regional director for South Asia, Karin Hulshof, said concern was mounting for the safety and wellbeing of Children.
"They are in danger of succumbing to the elements as temperatures plummet," she said.
The quake lasted for up to 45 seconds early on Monday afternoon, creating cracks in walls across a wide region and leading to electricity blackouts.
Officials say more than 1,600 people in Pakistan were injured in Monday's quake, and more than 4,000 homes destroyed.